Viagra, Cialis and Levitra are well-know and firmly established ED medications of the pharmaceutical market. At the moment, it seems there are no remarkable and decent rivals to them. Is that true? Can you find something new and different to treat erectile dysfunction?

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Avanafil (Spedra and Stendra)

Avanafil is a medication belonging to the group of PDE5 (phosphodiesterase type five) inhibitors. It was approved by the FDA in 2012, a year later European Medicines Agency also issued an approval. Drugstores sell it under two names – Spedra and Stendra. Spedra is a commercial name for Europe, while Stendra brand is used in the United States. As avanafil belongs th the same pharmaceutical category as Cialis and Viagra, it acts the same way, but there are differences in the onset of action.

So what’s the key advantage of avanafil? The medication features a very fast effect. Its active substance reaches maximum concentration in the blood in about thirty minutes (while the same period of Viagra may last up to 2 hours). In addition, males can receive the needed effect 15 minutes after taking Spedra (Stendra) which is a great indicator. Avana is a generic name of this product.

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Udenafil (Zydena)

Udenafil has some similarities with Cialis, as its pharmacokinetics profile allows everyday use (along with the possibility for men to take it as needed). Like avanafil, this drug has a rapid onset of action, it also features long duration of effect.

However, this pharmaceutical substance has not yet gained approval from the US Food and Drug Administration, it is only available in a few countries: Russian Federation, South Korea, and the Philippines.

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Lodenafil and Mirodenafil

Lodenafil is a representative of a new generation of PDE5 inhibitors. Brazilian company Cristália Produtos Químicos e Farmacêuticos manufactures it in the form of a prodrug (brand name Helleva), which features better bioavailability in comparison with ordinary ED pills. The medication has undergone Phase 3 of clinical trials, but it has no FDA approval at the moment.

Mirodenafil is a South Korean development (by SK Group). It is sold in drugstores of this country under brand name Mvix, both as pills and orally disintegrating films.

It has been repeatedly studied, but as in the case of lodenafil this remedy hasn’t been approved by the US regulator.

Other Options and Further Perspectives

Besides pills, there are other remedies and tools for treating ED on the market, in particular, injections, sprays, creams, pellets, and penis vacuum devices (pumps). In addition, according to the study by P Ganesan Adaikan (National University of Singapore, 2016), increasing number of other agents in the pipeline, viz. NO donors, guanylate cyclase activators (GUCAs), potassium channel openers and Rho-kinase (ROCK) inhibitors offer significant promise of clinical usage in resistant cases. However, a long way must be traveled. The development and launch of a new drug on the market is not an easy process.


You may try some new treatments for ED, and avanafil seems the most safe and effective. However, Viagra and and other old-timers demonstrate higher studiedness (since they have been on the market for a long time). Therefore, the risk of unforeseen side effects when using them seems to be lower. Choose proven and popular remedies, however, if you are an experimenter by nature, you can try some new developments.

It’s a good moment to read our article: Cialis and Viagra Together: Is it Safe?

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